Methyl 1H-indazole-5-carboxylate → HCID 118251643, compound

HRID 2203170Notes

Reaction equation

HRID 2203170 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([CH2:11]O)[CH:10]=1)[N:7]([CH2:13][CH:14]([CH2:17][CH3:18])[CH2:15][CH3:16])[N:6]=[CH:5]2.[CH3:19][O:20][C:21]([C:23]1[CH:24]=[C:25]2[C:29](=[CH:30][CH:31]=1)[NH:28][N:27]=[CH:26]2)=[O:22]>>[CH3:19][O:20][C:21]([C:23]1[CH:24]=[C:25]2[C:29](=[CH:30][CH:31]=1)[N:28]([CH2:11][C:9]1[CH:10]=[C:2]([Br:1])[CH:3]=[C:4]3[C:8]=1[N:7]([CH2:13][CH:14]([CH2:17][CH3:18])[CH2:15][CH3:16])[N:6]=[CH:5]3)[N:27]=[CH:26]2)=[O:22]

Participants

3

Reactant 2

HCID 22260640Methyl 1H-indazole-5-carboxylateHCID 118251636HCID 118251636, compound

Product 1

HCID 118251643HCID 118251643, compoundYield 47%

Procedure

Compound 31 was prepared following general method 3A, using compound 23 as a starting material and 1H-indazole-5-carboxylic acid methyl ester as the heterocycle. Yield: 47%.

Sources & evidence

ORD record
ord-a6646511f11541f6adc5e2ff898b250f
Source dataset
uspto-grants-2016_06
Patent number
US09365569B2

Reaction notes

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