(5-Chloro-1-isobutyl-1H-indazole-7-yl)-methanol → 1-(5-Chloro-1-isobutyl-1H-indazol-7-ylmethyl)-1H-benzoimidazole-5-carboxylic acid methyl ester
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([CH2:11]O)[CH:10]=1)[N:7]([CH2:13][CH:14]([CH3:16])[CH3:15])[N:6]=[CH:5]2.[CH3:17][O:18][C:19]([C:21]1[CH:29]=[CH:28][C:24]2[NH:25][CH:26]=[N:27][C:23]=2[CH:22]=1)=[O:20]>>[CH3:17][O:18][C:19]([C:21]1[CH:29]=[CH:28][C:24]2[N:25]([CH2:11][C:9]3[CH:10]=[C:2]([Cl:1])[CH:3]=[C:4]4[C:8]=3[N:7]([CH2:13][CH:14]([CH3:16])[CH3:15])[N:6]=[CH:5]4)[CH:26]=[N:27][C:23]=2[CH:22]=1)=[O:20]Participants
3
Procedure
Compound 34 was prepared following general method 3A, using compound 17 as a starting material and 1H-benzoimidazole-5-carboxylic acid methyl ester as the heterocycle. Yield: 40%.
Sources & evidence
- ORD record
- ord-83c104253b264da7a26b7a1fdfe73b27
- Source dataset
- uspto-grants-2016_06
- Patent number
- US09365569B2
Reaction notes
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