(5-Bromo-1-isobutyl-1H-indazole-7-yl)-methanol → 1-(5-Bromo-1-isobutyl-1H-indazol-7-ylmethyl)-3-methyl-1H-indazole-5-carboxylic acid methyl ester
Reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([CH2:11]O)[CH:10]=1)[N:7]([CH2:13][CH:14]([CH3:16])[CH3:15])[N:6]=[CH:5]2.[CH3:17][O:18][C:19]([C:21]1[CH:22]=[C:23]2[C:27](=[CH:28][CH:29]=1)[NH:26][N:25]=[C:24]2[CH3:30])=[O:20]>>[CH3:17][O:18][C:19]([C:21]1[CH:22]=[C:23]2[C:27](=[CH:28][CH:29]=1)[N:26]([CH2:11][C:9]1[CH:10]=[C:2]([Br:1])[CH:3]=[C:4]3[C:8]=1[N:7]([CH2:13][CH:14]([CH3:16])[CH3:15])[N:6]=[CH:5]3)[N:25]=[C:24]2[CH3:30])=[O:20]Participants
3
Procedure
Compound 37 was prepared following general method 3A, using compound 18 as a starting material and 3-methyl-1H-indazole-5-carboxylic acid methyl ester as the heterocycle. Yield: 76%.
Sources & evidence
- ORD record
- ord-38ae827710fc4259a82f25d99c6a8f29
- Source dataset
- uspto-grants-2016_06
- Patent number
- US09365569B2
Reaction notes
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