(5-Bromo-1-isobutyl-1H-indazole-7-yl)-methanol → HCID 118251600, compound

HRID 2203176Notes

Reaction equation

HRID 2203176 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([CH2:11]O)[CH:10]=1)[N:7]([CH2:13][CH:14]([CH3:16])[CH3:15])[N:6]=[CH:5]2.[CH3:17][O:18][C:19]([C:21]1[CH:22]=[C:23]2[C:29]([CH3:30])=[N:28][NH:27][C:24]2=[N:25][CH:26]=1)=[O:20]>>[CH3:17][O:18][C:19]([C:21]1[CH:22]=[C:23]2[C:29]([CH3:30])=[N:28][N:27]([CH2:11][C:9]3[CH:10]=[C:2]([Br:1])[CH:3]=[C:4]4[C:8]=3[N:7]([CH2:13][CH:14]([CH3:16])[CH3:15])[N:6]=[CH:5]4)[C:24]2=[N:25][CH:26]=1)=[O:20]

Participants

3

Reactant 2

HCID 118251640(5-Bromo-1-isobutyl-1H-indazole-7-yl)-methanolHCID 178498762HCID 178498762, compound

Product 1

HCID 118251600HCID 118251600, compoundYield 50%

Procedure

Compound 38 was prepared following general method 3A, using compound 18 as a starting material and 3-Methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid methyl ester as the heterocycle. Yield: 50%.

Sources & evidence

ORD record
ord-fa7867de9b334e3790518cce29f03b33
Source dataset
uspto-grants-2016_06
Patent number
US09365569B2

Reaction notes

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