HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2203190Generated: November 1, 2026
Chloroacetaldehyde → HCID 90427811, compound
https://huagongshe.com/reaction/2203190
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chloroacetaldehyde | HCID 33 | — |
| Reactant | 2-Amino-4,6-dimethyl-3-pyridinecarbonitrile | HCID 230471 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 90427811 | HCID 90427811 | 75% |
Reaction Steps
To a stirred solution of compound 2-amino-4,6-dimethylnicotinonitrile (1 equiv.) in water was added chloroacetaldehyde (55% aq. solution) (1.2 equiv.) and reaction was heated at 80° C. for 16 h. On completion, it was quenched by 1N NaOH till pH 8. Solid precipitated was filtered and vacuum dried to afford the title compound (75% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09365570B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-bccb5f26f4754665b1009a4ec0532d0b |
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| Source note | uspto-grants-2016_06 |
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