反应详情

温度

80 °C

To a stirred solution of compound 2-amino-4-methylnicotinonitrile (1 equiv.) in water was added chloroacetaldehyde (55% aq. solution) (1.2 equiv.) and the reaction was heated at 80° C. for 16 h. On completion, it was quenched by 1N NaOH till pH 8. Solid precipitated was filtered and vacuum dried to afford the title compound (75% yield).

1. customOn completion, it was quenched by 1N NaOH till pH 8
2. customSolid precipitated
3. filtrationwas filtered
4. customvacuum dried