HCID 90426456, compound → HCID 90427279, compound

HRID 2203194Notes

Reaction equation

HRID 2203194 reaction equation
[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([C:5]([C:12]#[N:13])=[C:6]([CH3:11])[CH:7]=[CH:8]2)=[N:3]1>CO.N.[Ni]>[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([C:5]([CH2:12][NH2:13])=[C:6]([CH3:11])[CH:7]=[CH:8]2)=[N:3]1

Participants

5

Reactant 1

HCID 90426456HCID 90426456, compound

Product 1

HCID 90427279HCID 90427279, compound

Reagents, catalysts & solvents 3

HCID 935NickelCatalystHCID 222AmmoniaSolventHCID 887MethanolSolvent

Procedure

To a solution of 2,6-dimethyl-2H-indazole-7-carbonitrile (1 equiv.) in methanol and aq. ammonia solution (9:1), catalytic amount of Raney Nickel was added. Reaction mass was stirred at room temperature under hydrogen pressure (balloon pressure) for 2-5 h. On completion of reaction, it was filtered through celite bed and filtrate was concentrated under reduce pressure to afford the title compound (quant. yield).

Workup

  1. customReaction mass
  2. customOn completion of reaction, it
  3. filtrationwas filtered through celite bed and filtrate
  4. concentrationwas concentrated

Sources & evidence

ORD record
ord-1ac61d667cfe47908caea0afde912756
Source dataset
uspto-grants-2016_06
Patent number
US09365570B2

Reaction notes

Loading…