2-Methyl-2H-indazole-7-carbonitrile → HCID 44119221, compound

HRID 2203196Notes

Reaction equation

HRID 2203196 reaction equation
[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([C:5]([C:11]#[N:12])=[CH:6][CH:7]=[CH:8]2)=[N:3]1>CO.N.[Ni]>[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([C:5]([CH2:11][NH2:12])=[CH:6][CH:7]=[CH:8]2)=[N:3]1

Participants

5

Reactant 1

HCID 441192602-Methyl-2H-indazole-7-carbonitrile

Product 1

HCID 44119221HCID 44119221, compound

Reagents, catalysts & solvents 3

HCID 935NickelCatalystHCID 222AmmoniaSolventHCID 887MethanolSolvent

Procedure

To a solution of 2-methyl-2H-indazole-7-carbonitrile (1 equiv.) in methanol and aq. ammonia solution (9:1), catalytic amount of Raney Nickel was added. Reaction mass was stirred at room temperature under hydrogen pressure (balloon pressure) for 2-5 h. On completion of reaction, it was filtered through celite bed and filtrate was concentrated under reduce pressure to afford the title compound (quant. yield).

Workup

  1. customReaction mass
  2. customOn completion of reaction, it
  3. filtrationwas filtered through celite bed and filtrate
  4. concentrationwas concentrated

Sources & evidence

ORD record
ord-00b707e22aea479580541497fb8201d3
Source dataset
uspto-grants-2016_06
Patent number
US09365570B2

Reaction notes

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