HCID 66878002, compound → HCID 86641930, compound

HRID 220320Notes

Reaction equation

HRID 220320 reaction equation
[OH:1][C:2]1([CH2:16][C:17](O)=O)[CH2:7][CH:6]2[CH2:8][CH2:9][CH:3]1[CH:4]=[C:5]2[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[F:20][C:21]([F:41])([F:40])[C:22]1[C:30]2[N:29]=[C:28]([CH2:31][CH2:32][CH2:33][NH:34][CH3:35])[NH:27][C:26]=2[CH:25]=[C:24]([C:36]([F:39])([F:38])[F:37])[CH:23]=1>>[F:41][C:21]([F:20])([F:40])[C:22]1[C:30]2[N:29]=[C:28]([CH2:31][CH2:32][CH2:33][N:34]([CH3:35])[CH2:17][CH2:16][C:2]3([OH:1])[CH2:7][CH:6]4[CH2:8][CH2:9][CH:3]3[CH:4]=[C:5]4[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[NH:27][C:26]=2[CH:25]=[C:24]([C:36]([F:37])([F:38])[F:39])[CH:23]=1

Participants

3

Reactant 2

HCID 66878002HCID 66878002, compoundHCID 86641931HCID 86641931, compound

Product 1

HCID 86641930HCID 86641930, compound

Procedure

Prepared according to procedures P2.2 to P2.3 in Example 21 using rac-(1R*,2R*,4R*)-(2-hydroxy-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl)-acetic acid and [3-(4,6-bis-trifluoromethyl-1H-benzoimidazol-2-yl)-propyl]-methyl-amine.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-b082c671035e4eddba226a28a6bdce96
Source dataset
uspto-grants-2012_06
Patent number
US08202885B2

Reaction notes

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