HRID220320

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID66878002

未命名化合物

结构：CNCCCc1nc2c(C(F)(F)F)cc(C(F)(F)F)cc2[nH]1

HCID86641931

未命名化合物

PRODUCTS

生成物

结构：CN(CCCc1nc2c(C(F)(F)F)cc(C(F)(F)F)cc2[nH]1)CCC1(O)CC2CCC1C=C2c1ccccc1

HCID86641930

未命名化合物

PROCEDURE

实验过程

Prepared according to procedures P2.2 to P2.3 in Example 21 using rac-(1R*,2R*,4R*)-(2-hydroxy-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl)-acetic acid and [3-(4,6-bis-trifluoromethyl-1H-benzoimidazol-2-yl)-propyl]-methyl-amine.

WORKUP

后处理

customPrepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b082c671035e4eddba226a28a6bdce96
来源数据集: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08202885B2
来源说明: uspto-grants-2012_06

反应 SMILES

[OH:1][C:2]1([CH2:16][C:17](O)=O)[CH2:7][CH:6]2[CH2:8][CH2:9][CH:3]1[CH:4]=[C:5]2[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[F:20][C:21]([F:41])([F:40])[C:22]1[C:30]2[N:29]=[C:28]([CH2:31][CH2:32][CH2:33][NH:34][CH3:35])[NH:27][C:26]=2[CH:25]=[C:24]([C:36]([F:39])([F:38])[F:37])[CH:23]=1>>[F:41][C:21]([F:20])([F:40])[C:22]1[C:30]2[N:29]=[C:28]([CH2:31][CH2:32][CH2:33][N:34]([CH3:35])[CH2:17][CH2:16][C:2]3([OH:1])[CH2:7][CH:6]4[CH2:8][CH2:9][CH:3]3[CH:4]=[C:5]4[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[NH:27][C:26]=2[CH:25]=[C:24]([C:36]([F:37])([F:38])[F:39])[CH:23]=1