1H-Indazole-5-boronic acid pinacol ester → HCID 71765584, compound

HRID 2203231Notes

Reaction equation

HRID 2203231 reaction equation
CC1(C)C(C)(C)OB([C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[NH:14][N:13]=[CH:12]3)O1.[NH2:19][C:20]1[C:29]2[C:24](=[C:25](Br)[C:26]([CH2:30][CH3:31])=[CH:27][CH:28]=2)[N:23]=[N:22][C:21]=1[C:33]([NH2:35])=[O:34]>>[NH2:19][C:20]1[C:29]2[C:24](=[C:25]([C:9]3[CH:10]=[C:11]4[C:15](=[CH:16][CH:17]=3)[NH:14][N:13]=[CH:12]4)[C:26]([CH2:30][CH3:31])=[CH:27][CH:28]=2)[N:23]=[N:22][C:21]=1[C:33]([NH2:35])=[O:34]

Participants

3

Reactant 2

HCID 177504691H-Indazole-5-boronic acid pinacol esterHCID 89825402HCID 89825402, compound

Product 1

HCID 71765584HCID 71765584, compound

Procedure

The title compound was prepared in a manner similar to EXAMPLE 1 using 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole and 4-amino-8-bromo-7-ethylcinnoline-3-carboxamide. ESI-MS m/z [M+H]+ 333.

Sources & evidence

ORD record
ord-fb842445cf964ec8be0c0988e7f8b5e2
Source dataset
uspto-grants-2016_06
Patent number
US09365566B2

Reaction notes

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