Lithium Hydroxide → HCID 90077540, compound

Participants

Reaction Steps

ethyl 6-chloro-4-((3-(trifluoromethyl)phenyl)amino)-1,5-naphthyridine-3-carboxylate (3.95 g, 10 mmol) was dissolved in 50 mL methanol and 50 mL tetrahydrofuran. To the resulting mixture was added dropwise a solution of lithium hydroxide (1.26 g, 30 mmol) in water (50 mL). After the completion of the dropwise addition, the resulting mixture is reacted at room temperature for 4 hrs. The reaction was concentrated, and 200 mL water was added. The resulting mixture was adjusted with hydrochloric acid to pH=3. The solid was separated, and dried in vacuum to obtain a yellow solid (3.6 g).

Provenance & Evidence