Ethyl chloroformate → HCID 90077618, compound

Participants

Reaction Steps

N-(4-methoxybenzyl)-6-chloro-4-(3-(trifluoromethyl)phenylamino)-1,5-naphthyridine-3-carboxamide (4.5 g, 9.2 mmol) is suspended in ethyl chloroformate (50 mL). The resulting mixture was added to 90° C., stirred for 120 hrs, rotary-evaporated to remove the volatile substance, and separated by silicagel column chromatography (EtOAc/PE=0-1/4) to obtain a yellow oil of 9-chloro-3-(4-methoxybenzyl)-1-(3-(trifluoromethyl)phenyl)pyrimido[5,4-c][1,5]naphthyridine-2,4(1H,3H)-dione (700 mg).

Provenance & Evidence