Cerate(2-), hexakis(nitrato-kappaO)-, potassium (1:2), (OC-6-11)- → HCID 90077584, compound

Participants

Reaction Steps

9-chloro-3-(4-methoxybenzyl)-1-(3-(trifluoromethyl)phenyl)pyrimidino[5,4-c][1,5]naphthyridine-2,4(1H,3H)-dione (700 mg, 1.36 mmol) was dissolved in acetonitrile (40 mL) and water (10 mL). Ammonium ceric nitrate (2.9 g, 5.65 mmol) was added in batch at room temperature. The reaction mixture was stirred at room temperature for 18 hrs, and then rotary-evaporated to remove the solvent. The resulting crude product was separated by silicagel column chromatography (EtOAc/PE=0-1/4) to obtain a yellow solid (400 mg).

Provenance & Evidence