4-Methylphenyl isocyanate → HCID 178426622, compound

Participants

Reaction Steps

In a manner similar to the procedure described in Example 7, 3-(4-aminophenyl)-2,3,4,7-tetrahydro-6H-pyrimido[1,2-c]quinazolin-6-one (20.2 mg, 0.069 mmol) and para-tolyl isocyanate (0.0096 mL, 0.076 mmol) were reacted to give the title compound as a pale tan solid (25.5 mg, 87%). 1H NMR (DMSO-d6) δ: 10.68 (s, 1H), 8.59 (s, 1H), 8.53 (s, 1H), 7.98 (d, J=7.9 Hz, 1H), 7.40-7.45 (m, 3H), 7.33 (d, J=8.2 Hz, 2H), 7.23 (d, J=8.5 Hz, 2H), 7.05-7.09 (m, 3H), 7.01 (d, J=8.2 Hz, 1H), 4.22 (dt, J=12.6, 3.5 Hz, 1H), 3.72 (dt, J=16.0, 3.4 Hz, 1H), 3.51-3.59 (m, 2H), 2.92-2.99 (m, 1H), 2.24 (s, 3H).

Provenance & Evidence