Hydroxylamine → HCID 133681488, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 2-methylcyanoacetate (5 g, 39 mmol) and hydroxylamine (2.6 g, 39 mmol) were dissolved in 50 mL of MeOH. The solution was heated at the 50° C. overnight. The solution was then concentrated and the residue purified by silica gel chromatography using a hexanes/EtOAc gradient to give the indicated product. 1H NMR δ (ppm) (DMSO-d6): 9.05 (1H, s), 5.40 (2H, s), 4.06 (2H, dd, J=12.8, 7.0 Hz), 3.15 (1H, m), 1.24 (3H, d, J=7.2 Hz), 1.18 (3H, t, J=7.1 Hz). m/z=161.1 (M+H)

Provenance & Evidence