HCID 77230841, compound → HCID 77230840, compound

Participants

Reaction Conditions

Reaction Steps

To the intermediate from Step A (1.46 g, 8.63 mmol) in 20 mL of CH3CN at room temperature was added a solution of AuCl3 (0.262 g, 0.863 mmol) in 5 mL of CH3CN. The resulting mixture was stirred at 50° C. for 14 hours and concentrated. The residue was purified by silica gel chromatography using a hexanes/EtOAc gradient to give the indicated product (pale yellow oil). 1H NMR (CDCl3, 500 MHz) δ 6.78 (1H, s), 4.07 (1H, q, J=7.4 Hz), 3.79 (3H, s), 2.37 (3H, s), 1.67 (3H, d, J=7.5 Hz).

Provenance & Evidence