HCID 89438437, compound → HCID 54675675, compound

Participants

Reaction Steps

A DMF (2 mL) solution of the crude intermediate from Step D (73 mg, 0.12 mmol), copper (I) iodide (23 mg, 0.12 mmol) and N,N′-dimethylaminocyclohexane (17 mg, 0.12 mmol) was stirred at room temperature for 30 minutes. The DMF reaction mixture was filtered and purified by reverse phase HPLC using a water/acetonitrile (with 0.1% TFA) gradient to give the indicated compound. 1H NMR (500 MHz, CH3CN-d3): δ 9.17 (s, 1H); 8.83-8.78 (m, 1H); 7.84 (d, T=3.7 Hz, 1H); 7.54-7.49 (m, 1H); 7.38-7.28 (m, 5H); 5.38 (s, 2H); 3.31-3.26 (m, 2H); 2.73-2.66 (m, 2H); 1.82 (s, 3H). m/z=537.2 (M+H).

Provenance & Evidence