6-Chloro-3-(3,3,4,4,4-pentafluorobutyl)imidazo[1,5-a]pyridine-1-carbonitrile → 6-Chloro-3-(3,3,4,4,4-pentafluorobutyl)imidazo[1,5-a]pyridine-1-carboximidamide

Participants

Reaction Conditions

Reaction Steps

Trimethyl aluminum (2.0 M toluene, 10 mL, 20 mmol) was added to ammonium chloride (1.07 g, 20 mmol) suspended in toluene (30 mL) at 0° C. The solution was then stirred at room temperature for 2 hours to give a 0.5 M amino(chloro)methylaluminum solution in toluene. To the intermediate from Step I (2 g, 6.33 mmol) in toluene (1 mL) was added amino(chloro)methylaluminum (40 mL of 0.5 M solution in toluene, 20 mmol). The resulting mixture was left stirring at 100° C. for 18 hours. The reaction mixture was cooled to room temperature and quenched with silica-gel and 1:1 methanol-chloroform (50 mL). The resulting slurry was stirred vigorously for 30 minutes. The reaction mixture was filtered through a silca gel pad (1″) and washed with methanol. The filtrate was concentrated. The residue was suspended in water and extracted with 30% IPA/CHCl3 (3×). The organic layer was concentrated in vacuo to yield a brown solid. m/z=340.8 (M+1).

Provenance & Evidence