Cyclopropylamine → HCID 86679017, compound

HRID 2203379Notes

Reaction equation

HRID 2203379 reaction equation
[CH3:1][C:2]1([C:32](OCC)=[O:33])[C:10]2[C:9]([NH:11][CH3:12])=[N:8][C:7]([C:13]3[C:21]4[C:16](=[N:17][CH:18]=[CH:19][CH:20]=4)[N:15]([CH2:22][CH2:23][C:24]([F:30])([F:29])[C:25]([F:28])([F:27])[F:26])[N:14]=3)=[N:6][C:5]=2[NH:4][C:3]1=[O:31].[CH:37]1([NH2:40])[CH2:39][CH2:38]1>CO>[CH:37]1([NH:40][C:32]([C:2]2([CH3:1])[C:10]3[C:9]([NH:11][CH3:12])=[N:8][C:7]([C:13]4[C:21]5[C:16](=[N:17][CH:18]=[CH:19][CH:20]=5)[N:15]([CH2:22][CH2:23][C:24]([F:30])([F:29])[C:25]([F:28])([F:27])[F:26])[N:14]=4)=[N:6][C:5]=3[NH:4][C:3]2=[O:31])=[O:33])[CH2:39][CH2:38]1

Participants

4

Reactant 2

HCID 69828CyclopropylamineHCID 86679018HCID 86679018, compound

Product 1

HCID 86679017HCID 86679017, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

The intermediate from Step B above (65 mg, 0.127 mmol) and cyclopropylamine (0.088 mL, 1.266 mmol) in MeOH (1 mL) were sealed in a microwave tube and heated at 80° C. for 2 days.

Sources & evidence

ORD record
ord-a2d7f718d991429ca47ff105ae0e6375
Source dataset
uspto-grants-2016_06
Patent number
US09365574B2

Reaction notes

Loading…