HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2203393Generated: October 31, 2026
1-Bromo-3-methanesulfonylpropane → (3-{5-Cyano-2-[(R)-6-methoxycarbonyl-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidin-5-yl]-phenyl}-propyl)-(3-methanesulfonyl-propyl)-dimethyl-ammonium formate
https://huagongshe.com/reaction/2203393
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Bromo-3-methanesulfonylpropane | HCID 51892082 | — |
| Reactant | (R)-5-[4-Cyano-2-(3-dimethylamino-propyl)-phenyl]-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester | HCID 76284943 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (3-{5-Cyano-2-[(R)-6-methoxycarbonyl-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidin-5-yl]-phenyl}-propyl)-(3-methanesulfonyl-propyl)-dimethyl-ammonium formate | HCID 76284989 | 65.7% |
Reaction Steps
To a solution of Example 12 (150 mg, 0.28 mmol) in MeCN (2 mL) was added 1-bromo-3-methanesulfonyl-propane (225 mg, 1.12 mmol). The resulting mixture was heated at 90° C. for 40 minutes using microwave irradiation. The solvent was removed in vacuo and the resultant residue was purified by reverse phase chromatography (MDAP), giving the title compound as an off-white solid (65 mg)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09365577B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-e463bc89a36e4ad39ac774f7e77172df |
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| Source note | uspto-grants-2016_06 |
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