HCID 89544255, compound → HCID 71558618, compound

Participants

Reaction Steps

Following the procedure as described in EXAMPLE 44, making non-critical variations to replace 4-chloro-2-(pyrazolo[1,5-a]pyrimidin-3-yl)phenol with bis(tert-butyl (5-(2-(4-((1H-pyrazol-1-yl)sulfonyl)-2,5-difluorophenoxy)-5-chlorophenyl)benzo[d]isoxazol-3-yl))carbamate (0.36 g, 0.52 mmol), 5-(2-(4-((1H-pyrazol-1-yl)sulfonyl)-2,5-difluorophenoxy)-5-chlorophenyl)benzo[d]isoxazol-3-amine was obtained as a colorless solid in 2% yield (0.005 g): 1H NMR (300 MHz, CDCl3) δ 8.11-8.10 (m, 1H), 7.78 (dd, J=6.4, 9.3 Hz, 1H), 7.72 (s, 1H), 7.62-7.59 (m, 2H), 7.50 (d, J=2.4 Hz, 1H), 7.41-7.37 (m, 2H), 7.08 (d, J=8.6 Hz, 1H), 6.40-6.35 (m, 2H) (NH not observed); MS (ES+) m/z 502.7 (M+1), 504.7 (M+1).

Provenance & Evidence