6-Bromo-1H-benzimidazole--hydrogen chloride (1/1) → HCID 178516061, compound

HRID 2203440Notes

Reaction equation

HRID 2203440 reaction equation
BrC1N2C=NC=C2C(=O)N(C[C:13]2[CH:18]=[CH:17][C:16]([O:19]C)=[CH:15][CH:14]=2)C=1.[ClH:21].Br[C:23]1[CH:24]=[CH:25][C:26]2[N:30]=[CH:29][NH:28][C:27]=2[CH:31]=1>>[NH:28]1[C:27]2[CH:31]=[CH:23][C:24]([C:15]3[CH:14]=[C:13]([Cl:21])[CH:18]=[CH:17][C:16]=3[OH:19])=[CH:25][C:26]=2[N:30]=[CH:29]1

Participants

3

Reactant 2

HCID 532169206-Bromo-1H-benzimidazole--hydrogen chloride (1/1)HCID 895440475-bromo-7-(4-methoxybenzyl)imidazo[1,5-a]pyrazin-8(7H)-one

Product 1

HCID 178516061HCID 178516061, compoundYield 43%

Procedure

Following the procedure as described in EXAMPLE 4 and making non-critical variations to replace 5-bromo-7-(4-methoxybenzyl)imidazol[1,5-a]pyrazin-8(7H)-one with 6-bromo-1H-benzo[d]imidazole hydrochloride salt, 2-(1H-benzo[d]imidazol-5-yl)-4-chlorophenol was obtained as a beige solid in 43% yield (0.110 g): MS (ES+) m/z 245.0 (M+1), 246.9 (M+1).

Sources & evidence

ORD record
ord-71736f25173e444b891943da68e6a819
Source dataset
uspto-grants-2016_06
Patent number
US09365578B2

Reaction notes

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