HCID 71558617, compound → HCID 71559220, compound

Participants

Reaction Steps

Following the procedure as described in EXAMPLE 44, making non-critical variations to replace 4-chloro-2-(pyrazolo[1,5-a]pyrimidin-3-yl)phenol with 4-((3-(3-aminobenzo[d]isoxazol-5-yl)pyridin-2-yl)oxy)-N-(2,4-dimethoxybenzyl)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide, 4-((3-(3-aminobenzo[d]isoxazol-5-yl)pyridin-2-yl)oxy)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide was obtained as a colorless solid in 7% yield (0.01 g): 1H NMR (300 MHz, DMSO-d6) δ 8.52 (s, 1H), 8.18-8.10 (m, 2H), 8.02 (dd, J=7.5, 1.8 Hz, 1H), 7.87-7.77 (m, 2H), 7.69 (dd, J=10.0, 6.0 Hz, 1H), 7.57 (d, J=8.7 Hz, 1H), 7.36 (dd, J=7.4, 4.9 Hz, 1H), 6.51 (br s, 2H); MS (ES+) m/z 502.6 (M+1).

Provenance & Evidence