HCID 71558469, compound → HCID 71559221, compound

Participants

Reaction Steps

Following the procedure as described in EXAMPLE 44, making non-critical variations to replace 4-chloro-2-(pyrazolo[1,5-a]pyrimidin-3-yl)phenol with 4-(3-(3-aminobenzo[d]isoxazol-5-yl)-2-oxopyridin-1(2H)-yl)-N-(2,4-dimethoxybenzyl)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide, 4-(3-(3-aminobenzo[d]isoxazol-5-yl)-2-oxopyridin-1(2H)-yl)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide was obtained as a colorless solid in 23% yield (0.04 g): 1H NMR (300 MHz, DMSO-d6) δ 8.22 (d, J=1.4 Hz, 1H), 8.04 (s, 1H), 7.82-7.67 (m, 5H), 7.46 (d, J=8.8 Hz, 1H), 6.51 (dd, J=6.9, 6.9 Hz, 1H), 6.45 (br s, 2H); MS (ES+) m/z 502.7 (M+1).

Provenance & Evidence