HCID 58005640, compound → HCID 90397808, compound

HRID 2203458Notes

Reaction equation

HRID 2203458 reaction equation
BrC1N2C=NC=C2C(=O)[N:4]([CH2:12][C:13]2C=C[C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)C=1.Br[C:22]1[CH:23]=[CH:24][C:25]2[O:29][N:28]=[C:27]([N:30]([C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39])[C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32])[C:26]=2[CH:45]=1>>[CH3:20][O:19][C:16]1[C:15]([C:22]2[CH:23]=[CH:24][C:25]3[O:29][N:28]=[C:27]([N:30]([C:31]([O:33][C:34]([CH3:35])([CH3:36])[CH3:37])=[O:32])[C:38]([O:40][C:41]([CH3:42])([CH3:44])[CH3:43])=[O:39])[C:26]=3[CH:45]=2)=[CH:14][CH:13]=[CH:12][N:4]=1

Participants

3

Reactant 2

HCID 58005640HCID 58005640, compoundHCID 895440475-bromo-7-(4-methoxybenzyl)imidazo[1,5-a]pyrazin-8(7H)-one

Product 1

HCID 90397808HCID 90397808, compoundYield 71%

Procedure

Following the procedure as described in EXAMPLE 4 and making non-critical variations to replace 5-bromo-7-(4-methoxybenzyl)imidazo[1,5-a]pyrazin-8(7H)-one with di-tert-butyl (5-bromo-1,2-benzoxazol-3-yl)imidodicarbonate, di-tert-butyl [5-(2-methoxypyridin-3-yl)-1,2-benzoxazol-3-yl]imidodicarbonate was obtained as a yellow solid in 71% yield (0.471 g): MS (ES+) m/z 441.9 (M+1).

Sources & evidence

ORD record
ord-72fd473f11e54efaaf650497dff7de87
Source dataset
uspto-grants-2016_06
Patent number
US09365578B2

Reaction notes

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