HRID2203477

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCOc1cc(OC2CC3C(=O)NC4(C(=O)O)CC4C=CCCCCN(C)C(=O)C3C2)c2cccc(C)c2n1

HCID68694508

17-[2-Ethoxy-8-methylquinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid

C30H37N3O6

结构：CCOc1cc(OC2CC3C(=O)NC4(C(=O)NS(=O)(=O)C5CC5)CC4C=CCCCCN(C)C(=O)C3C2)c2ccc(OC)c(C)c2n1

HCID68696188

未命名化合物

PRODUCTS

生成物

结构：CCOc1cc(OC2CC3C(=O)NC4(C(=O)NS(=O)(=O)C5CC5)CC4C=CCCCCN(C)C(=O)C3C2)c2cccc(C)c2n1

HCID74348600

未命名化合物

PROCEDURE

实验过程

The title compound (13) was prepared from 17-[2-ethoxy-8-methylquinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid (12) following the procedure reported for synthesis of N-[17-[2-ethoxy-7-methoxy-8-methylquinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo-[13.3.0.04,6]octadec-7-ene-4-carbonyl](cyclopropyl)sulfonamide (3): m/z=639 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e74d07b7e60f4f91bbfdd8a38b6d5bc1
来源数据集: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09365582B2
来源说明: uspto-grants-2016_06

反应 SMILES

C(OC1C=C(OC2CC3C(C(=O)N(C)CCCCC=CC4C(C(O)=O)(NC3=O)C4)C2)C2C(=C(C)C=CC=2)N=1)C.[CH2:40]([O:42][C:43]1[CH:52]=[C:51]([O:53][CH:54]2[CH2:71][CH:70]3[CH:56]([C:57](=[O:83])[N:58]([CH3:82])[CH2:59][CH2:60][CH2:61][CH2:62][CH:63]=[CH:64][CH:65]4[C:67]([C:73]([NH:75][S:76]([CH:79]5[CH2:81][CH2:80]5)(=[O:78])=[O:77])=[O:74])([NH:68][C:69]3=[O:72])[CH2:66]4)[CH2:55]2)[C:50]2[C:45](=[C:46]([CH3:86])[C:47](OC)=[CH:48][CH:49]=2)[N:44]=1)[CH3:41]>>[CH2:40]([O:42][C:43]1[CH:52]=[C:51]([O:53][CH:54]2[CH2:71][CH:70]3[CH:56]([C:57](=[O:83])[N:58]([CH3:82])[CH2:59][CH2:60][CH2:61][CH2:62][CH:63]=[CH:64][CH:65]4[C:67]([C:73]([NH:75][S:76]([CH:79]5[CH2:81][CH2:80]5)(=[O:77])=[O:78])=[O:74])([NH:68][C:69]3=[O:72])[CH2:66]4)[CH2:55]2)[C:50]2[C:45](=[C:46]([CH3:86])[CH:47]=[CH:48][CH:49]=2)[N:44]=1)[CH3:41]