HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → Diisopropyl diazene-1,2-dicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Tert-butyl 4-hydroxypiperidine-1-carboxylate | HCID 643502 | — |
| Reactant | HCID 178517343 | HCID 178517343 | — |
| Product | Diisopropyl diazene-1,2-dicarboxylate | HCID 75555 | — |
Reaction Steps
Alternatively, a compound of Formula XXXV can react with a 1H-imidazo[4,5-c]quinolinol of Formula XXIII under the Mitsunobu reaction conditions described in step (9) of Reaction Scheme I. For example, combining a 1H-imidazo[4,5-c]quinolinol of Formula XXIII, triphenylphosphine, and tert-butyl 4-hydroxy-1-piperidinecarboxylate in THF at 5° C. or ambient temperature and slowly adding diisopropyl azodicarboxylate provides a compound of Formula XXXVII wherein Za is a bond and R10 is pentylene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365567B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-c67688c7c1fd4a5dbe0c053f684135e5 |
| Source note | uspto-grants-2016_06 |