反应详情

A modification of the general method described in Part J of Example 1 was followed using 8-benzyloxy-2-butyl-1-methyl-1H-imidazo[4,5-c]quinoline (14.65 g, 42.4 mmol) in lieu of 7-benzyloxy-1-(2-methylpropyl)-2-propyl-1H-imidazo[4,5-c]quinolin-4-amine. The reaction was placed under hydrogen pressure for 3.5 hours. The catalyst was removed by filtration and washed with ethyl acetate. The filtrate was concentrated under reduced pressure to a small volume, and hexanes were added. A precipitate formed, and the mixture was stored overnight in a refrigerator. The solid was isolated by filtration, washed with hexanes (500 mL), and dried for three days under high vacuum to provide 9.40 g of 2-butyl-1-methyl-1H-imidazo[4,5-c]quinolin-8-ol as a white solid, mp 219-220.2° C.

1. customfor 3.5 hours
2. customThe catalyst was removed by filtration
3. washwashed with ethyl acetate
4. concentrationThe filtrate was concentrated under reduced pressure to a small volume, and hexanes
5. additionwere added
6. customA precipitate formed
7. customThe solid was isolated by filtration
8. washwashed with hexanes (500 mL)
9. customdried for three days under high vacuum