反应详情

Sulfuryl chloride (0.248 mL, 3.05 mmol) was added dropwise to a solution of 1-(isopropylsulfonyl)propan-2-one (418 mg, 2.55 mmol) in 1:1 AcOH/DCM (16 ml) at 0° C. The reaction was stirred at rt for 4 h. The solvent was removed in vacuo, then diluted with dichloromethane. The organic layer was washed (2×) with saturated NaHCO3 solution, dried over Na2SO4, filtered, and concentrated to leave 800 mg of a colorless oil. The material was used without further purification.

1. customThe solvent was removed in vacuo
2. additiondiluted with dichloromethane
3. washThe organic layer was washed (2×) with saturated NaHCO3 solution
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated