Hydrochloric Acid → 2(3H)-Thiazolimine, 5-methyl-3-[3-(trifluoromethyl)phenyl]-

Participants

Reaction Steps

A mixture of 2- (acetylimino)-3- (3-trifluoromethylphenyl)-5-methylthiazoline (1 g) and hydrochloric acid (38%, 4 ml) in ethanol-water (1:2, 15 ml) was refluxed for 3 hours. Ethanol was removed by distillation under reduced pressure, and the residue was neutralized with potassium carbonate, extracted with ethyl acetate and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give 0.4 g of 2-imino-3- (3-trifluoromethylphenyl) -5-methylthiazoline (Compound (xi)).

Provenance & Evidence