HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2203654Generated: November 4, 2026
Ammonium Chloride → 5-Bromo-2-methylpyridin-3-amine
https://huagongshe.com/reaction/2203654
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 5-Bromo-2-methyl-3-nitropyridine | HCID 25067266 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Water ethanol | HCID 19096565 | — |
| Product | 5-Bromo-2-methylpyridin-3-amine | HCID 21964096 | 98.3% |
Reaction Steps
To a solution of 5-bromo-2-methyl-3-nitropyridine (8.0 g, 37 mmol) in 4:1 ethanol/water (250 mL) was added iron (16.5 g, 295 mmol) and ammonium chloride (15.8 g, 295 mmol). The mixture was stirred at 80° C. for 3 h. The mixture was filtered, and the filtrate was concentrated in vacuo to give 5-bromo-2-methylpyridin-3-amine (6.8 g, 99% crude yield), which was without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09365583B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-2d1f2c928771492a977480544466262b |
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| Source note | uspto-grants-2016_06 |
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