Morpholine → HCID 58180633, compound

HRID 220366Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH:7]1([N:10]([CH:37]2[CH2:39][CH2:38]2)[C:11]([C:13]2[N:34]([CH2:35][CH3:36])[C:16]3=[N:17][C:18]([NH:25][C:26]4[S:27][C:28]([C:31](O)=[O:32])=[CH:29][N:30]=4)=[C:19]4[N:23]=[CH:22][N:21]([CH3:24])[C:20]4=[C:15]3[CH:14]=2)=[O:12])[CH2:9][CH2:8]1>>[CH:37]1([N:10]([CH:7]2[CH2:8][CH2:9]2)[C:11]([C:13]2[N:34]([CH2:35][CH3:36])[C:16]3=[N:17][C:18]([NH:25][C:26]4[S:27][C:28]([C:31]([N:1]5[CH2:6][CH2:5][O:4][CH2:3][CH2:2]5)=[O:32])=[CH:29][N:30]=4)=[C:19]4[N:23]=[CH:22][N:21]([CH3:24])[C:20]4=[C:15]3[CH:14]=2)=[O:12])[CH2:38][CH2:39]1

Participants

Reactant 2

HCID 8083Morpholine

HCID 58180599HCID 58180599, compound

Product 1

HCID 58180633HCID 58180633, compound

Procedure

This compound was prepared according to Example 20 using morpholine and 2-(7-(dicyclopropylcarbamoyl)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-ylamino)thiazole-5-carboxylic acid (example 20A) to provide N,N-dicyclopropyl-6-ethyl-1-methyl-4-(5-(morpholine-4-carbonyl)thiazol-2-ylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide as a white solid.

Workup

customThis compound was prepared

Sources & evidence

ORD record: ord-36b4cea5483b487e8dc72df56d5088ed
Source dataset: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08202881B2

Reaction notes

Loading…