Ethyl diazoacetate → HCID 118161660, compound

Participants

Reaction Steps

To a solution of 2-oxaspiro[3.4]oct-6-ene (1.0 g, 9.2 mmol) and copper sulfate (145 mg, 0.907 mmol) in toluene (5 mL) was added a solution of ethyl 2-diazoacetate (2.64 g, 22.7 mmol) in toluene (20 mL) at 100° C. over 16 h. The reaction mixture was concentrated, and the resulting residue was purified by flash column chromatography (10% ethyl acetate in petroleum ether) to afford product as a brown oil (1.5 g, 84% yield).

Provenance & Evidence