Sodium Hydroxide → HCID 118161815, compound

Participants

Reaction Steps

To a solution of ethyl spiro[bicyclo[3.1.0]hexane-3,3′-oxetane]-6-carboxylate (1.5 g, 7.6 mmol) in ethanol (15 mL) was added sodium hydroxide (917 mg, 22.9 mmol) in water (5 mL). After 16 h, the reaction mixture was concentrated, and the resulting residue was dissolved with water (20 mL). The resulting solution was extracted with ethyl acetate (15 mL). The aqueous layer was acidified with 1 M aqueous HCl solution to pH=3, and the aqueous solution was extracted with dichloromethane (20 mL). The collected organic was dried over anhydrous sodium sulfate, filtered, and concentrated to provide a white solid (0.80 g, 62% yield).

Provenance & Evidence