N-Methylisopropylamine → HCID 58180516, compound

HRID 220368Notes

Reaction equation

[CH3:1][NH:2][CH:3]([CH3:5])[CH3:4].[CH:6]1([N:9]([CH:36]2[CH2:38][CH2:37]2)[C:10]([C:12]2[N:33]([CH2:34][CH3:35])[C:15]3=[N:16][C:17]([NH:24][C:25]4[S:26][C:27]([C:30]([OH:32])=O)=[CH:28][N:29]=4)=[C:18]4[N:22]=[CH:21][N:20]([CH3:23])[C:19]4=[C:14]3[CH:13]=2)=[O:11])[CH2:8][CH2:7]1>>[CH:6]1([N:9]([CH:36]2[CH2:38][CH2:37]2)[C:10]([C:12]2[N:33]([CH2:34][CH3:35])[C:15]3=[N:16][C:17]([NH:24][C:25]4[S:26][C:27]([C:30]([N:2]([CH:3]([CH3:5])[CH3:4])[CH3:1])=[O:32])=[CH:28][N:29]=4)=[C:18]4[N:22]=[CH:21][N:20]([CH3:23])[C:19]4=[C:14]3[CH:13]=2)=[O:11])[CH2:7][CH2:8]1

Participants

Reactant 2

HCID 78485N-Methylisopropylamine

HCID 58180599HCID 58180599, compound

Product 1

HCID 58180516HCID 58180516, compound

Procedure

This compound was prepared according to Example 20 using N-methylpropan-2-amine and 2-(7-(dicyclopropylcarbamoyl)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-ylamino)thiazole-5-carboxylic acid (example 20A) to provide 2-(7-(dicyclopropylcarbamoyl)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-ylamino)-N-isopropyl-N-methylthiazole-5-carboxamide

Workup

customThis compound was prepared

Sources & evidence

ORD record: ord-1f23ecf4303c41818ea7e2cadf811d30
Source dataset: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08202881B2

Reaction notes

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