HCID 118161615, compound → HCID 118161656, compound

Participants

Reaction Steps

To an ice-cooled solution of N-methoxy-N-methylspiro[bicyclo[3.1.0]hexane-3,3′-oxetane]-6-carboxamide (0.30 g, 1.4 mmol) in tetrahydrofuran (15 mL) was added methylmagnesium bromide (1 mL, 3M in tetrahydrofuran) dropwise. After 1 h, the reaction mixture was diluted with saturated aqueous ammonia chloride solution (10 mL), and the resulting solution was extracted with ethyl acetate (3×20 mL). The collected organic was concentrated to provide product as a brown oil (220 mg, 93% yield).

Provenance & Evidence