Ethyl Acetate → HCID 123334776, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (E)-3-(6-amino-5-(trifluoromethoxy)pyridin-3-yl)-1-(3-((tert-butyldiphenylsilyl)oxy)bicyclo[3.1.0]hexan-6-yl)-3-(methylthio)prop-2-en-1-one (0.70 g, 1.1 mmol) and hydrazine hydrate (5 mL) in ethanol (5 mL) was sealed in a microwave vessel and heated at 100° C. by microwave irradiation for 1 h. The reaction mixture was concentrated, and the resulting residue was purified by flash column chromatography (60% ethyl acetate in petroleum ether) to product as a white solid (0.50 g, 76% yield). LCMS (ESI) [MH]+=579.1.

Provenance & Evidence