HCID 123573018, compound → HCID 118161582, compound

Participants

Reaction Steps

A solution of 5-(5-(3-((tert-butyldiphenylsilyl)oxy)bicyclo[3.1.0]hexan-6-yl)-1-(cyclopropylmethyl)-1H-pyrazol-3-yl)-3-(trifluoromethoxy)pyridin-2-amine (0.30 g, 0.47 mmol) in tetrahydrofuran (2 mL) and triethylamine trihydrofluoride (2 mL) was heated to 60° C. for 16 h. The reaction was diluted with saturated aqueous sodium bicarbonate, and the resulting mixture was extracted with ethyl acetate (2×10 mL). The collected organic was washed with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, filtered, and concentrated. Purification by flash column chromatography (50% ethyl acetate in petroleum ether) provided product as a solid (140 mg, 75% yield). LCMS (ESI) [MH]+=394.9.

Provenance & Evidence