Dimethylamine → HCID 58180634, compound

HRID 220369Notes

Reaction equation

[CH3:1][NH:2][CH3:3].[CH:4]1([N:7]([CH:34]2[CH2:36][CH2:35]2)[C:8]([C:10]2[N:31]([CH2:32][CH3:33])[C:13]3=[N:14][C:15]([NH:22][C:23]4[S:24][C:25]([C:28]([OH:30])=O)=[CH:26][N:27]=4)=[C:16]4[N:20]=[CH:19][N:18]([CH3:21])[C:17]4=[C:12]3[CH:11]=2)=[O:9])[CH2:6][CH2:5]1>>[CH:4]1([N:7]([CH:34]2[CH2:35][CH2:36]2)[C:8]([C:10]2[N:31]([CH2:32][CH3:33])[C:13]3=[N:14][C:15]([NH:22][C:23]4[S:24][C:25]([C:28]([N:2]([CH3:3])[CH3:1])=[O:30])=[CH:26][N:27]=4)=[C:16]4[N:20]=[CH:19][N:18]([CH3:21])[C:17]4=[C:12]3[CH:11]=2)=[O:9])[CH2:6][CH2:5]1

Participants

Reactant 2

HCID 674Dimethylamine

HCID 58180599HCID 58180599, compound

Product 1

HCID 58180634HCID 58180634, compound

Procedure

This compound was prepared according to Example 20 using N,N-dimethylamine and 2-(7-(dicyclopropylcarbamoyl)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-ylamino)thiazole-5-carboxylic acid (example 20A) to give 2-(7-(dicyclopropylcarbamoyl)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-ylamino)-N,N-dimethylthiazole-5-carboxamide.

Workup

customThis compound was prepared

Sources & evidence

ORD record: ord-12762ed7f0314a78badef8920052ee36
Source dataset: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08202881B2

Reaction notes

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