N-Iodosuccinimide → HCID 58180567, compound

Participants

Reaction Conditions

Reaction Steps

N,N-Dicyclopropyl-4-(3-(1,3-dimethyl-1H-pyrazol-5-yl)thioureido)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide (example 41B, 41 mg, 0.083 mmol) was dissolved in chloroform (2780 μL) and cooled to 0° C. NIS (18.76 mg, 0.083 mmol) was slowly added and the reaction was warmed to room temperature. The reaction mixture was concentrated. Methanol and ether were added and the mixture was filtered. After standing for a week, product precipitated out of the solution. The product was triturated with methanol. N,N-Dicyclopropyl-4-(1,3-dimethyl-1H-pyrazolo[3,4-d]thiazol-5-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide was isolated as a pale yellow solid (8.1 mg, 20% yield).

Provenance & Evidence