Sodium Hydroxide → HCID 86691640, compound

Participants

Reaction Steps

Sodium hydroxide (0.67 g, 1.68 mmol) was added to a stirred solution of 8-(1H-imidazol-1-yl)octadecanoate (0.305 g, 0.84 mmol) in a mixture of methanol (9 ml) and water (3 ml) at 0° C., warmed to room temperature and stirring continued another 3 h. Methanol was removed from the mixture by evaporation. The pH was adjusted to 4 with 1N HCl, and the mixture extracted with dichloromethane (3×15 ml). The combined organic layers were washed with brine solution, dried on anhydrous MgSO4, and concentrated. Crude product was purified on silica gel column (5% methanol in dichloromethane) to obtain a gummy liquid (370 mg, 83%).

Provenance & Evidence