Ethanol → HCID 86691646, compound

Participants

Reaction Steps

13-(1H-imidazol-1-yl)octadecanenitrile (550 mg, 1.66 mmol) was dissolved in EtOH (10 ml) and water (5 ml), to which was then added NaOH (332 mg, 8.30 mmol) and the mixture refluxed for 16 hr. The reaction mixture was then concentrated and acidified with 1N HCl, extracted with DCM, washed with brine solution, dried over MgSO4 and concentrated. The crude product was purified by silica gel column (4% MeOH in DCM) to give 13-(1H-imidazol-1-yl)octadecanoic acid as a thick oil (470 mg, 81%).

Provenance & Evidence