Dicyclohexylcarbodiimide → HCID 71616257, compound

Participants

Reaction Steps

A stirred solution of 13-(1H-imidazol-1-yl)octadecanoic acid (365 mg, 1.041 mmol), (3-hydroxypropyl)triphenylphosphonium bromide (418 mg, 1.041 mmol) and DMAP (catalytic amount) in DCM (10 ml), was cooled to 0° C., to which was then added DCC (215 mg, 1.041 mmol) under N2 gas, and stirring continued overnight at room temperature. The reaction mixture was filtered and concentrated. The crude product was purified by silica gel column (5% MeOH in DCM) to give TPP-13-ISA as a gummy semi-solid (600 mg, 78%)

Provenance & Evidence