HCID 86691648, compound → HCID 86691647, compound

Participants

Reaction Steps

Diethyl 2-(12-hydroxydodecyl)malonate (3.91 g, 11.35 mmol) was dissolved in dry DCM (60 ml), then PCC (3.67 g, 17.025 mmol) was added portion-wise to it at 0° C. The reaction was allowed to warm to room temperature and stirring was continued for another 3 h. The reaction mixture was concentrated under reduced pressure and purified by silica gel column (8% EtOAc in Hexane) to give diethyl 2-(12-oxododecyl)malonate (2.84 g, 73%) as a colorless liquid.

Provenance & Evidence