Sodium Iodide → Iodomethyl pivalate

Participants

Reaction Steps

Chloromethyl pivalate (1.0 mL, 6.90 mmol) was added to a mixture of NaI (2.08 g, 13.80 mmol) and dry MeCN (10 mL). The reaction mixture was stirred at room temperature overnight in the dark. The mixture was evaporated to dryness. The resulting residue was dissolved in dichloromethane and washed with 5% aqueous NaHSO3 and brine. The organic layer was dried over Na2SO4 and evaporated to dryness. The resulting iodomethyl pivalate was used without further purification in the next step.

Provenance & Evidence