Thioacetamide → HCID 50991652, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-(2-chloroacetamido)-N,N-dicyclopropyl-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide (58.5 mg, 0.141 mmol) in DMF (176 μL) was added thioacetamide (12.71 mg, 0.169 mmol). The vial was capped and the reaction mixture was heated at 80° C. 3 h. The reaction mixture was concentrated in vacuo. The crude residue was taken up in MeOH and purified by prep-HPLC. N,N-Dicyclopropyl-6-ethyl-1-methyl-4-(2-methylthiazol-4-ylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide (4.05 mg, 6.6% yield) was isolated as an off-white solid.

Provenance & Evidence