HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 1-(3-Bromopyridin-2-yl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 3-Bromo-2-chloropyridine | HCID 693324 | — |
| Product | 1-(3-Bromopyridin-2-yl)piperazine | HCID 13298529 | — |
Reaction Steps
Alternatively, 3-bromo-2-chloropyridine may be used as shown in Scheme VIII. Thus, 3-bromo-2-chloropyridine (27) is heated with piperazine to provide 1-(3-bromopyridin-2-yl)piperazine (28), followed by Suzuki coupling of the phenyl moiety to provide the phenylpiperazine intermediate (25).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202873B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-2f53b5e6ae9c4b2fb35ad0ac6d14c993 |
| Source note | uspto-grants-2012_06 |