Water → HCID 58551415, compound

Participants

Reaction Steps

To a solution of 9′-fluoro-1-(2,2,2-trifluoroacetyl)spiro[piperidine-4,4′-pyrrolo[2,1-c][1,4]benzoxazine]-1′-carbonitrile (170 mg, 0.45 mmol) dissolved in MeOH (2.7 mL) was added K2CO3 (130 mg, 0.94 mmol) in one portion at rt. The reaction was monitored by LCMS until no starting material remained. Water was added (10 mL), and the organic solvent removed under vacuum. The product was extracted with dichloromethane (3×30 mL), the organic phases were combined, dried with sodium sulfate, filtered, concentrated to a white solid, which was used directly in next step without further purification (104 mg, 82%). ESI-MS m/z calc. 283.1, found 284.1 (M+1)+; Retention time 0.94 minutes (3 min run).

Provenance & Evidence