Hydrochloric Acid → HCID 67465554, compound

Participants

Reaction Steps

To a solution of tert-butyl 1′-acetylspiro[piperidine-4,4′-pyrrolo[2,1-c][1,4]benzoxazine]-1-carboxylate (600 mg, 1.57 mmol) in CH2Cl2 (6 mL) was added HCl in Dioxane (3.9 mL of 4 M, 15.7 mmol) and the mixture was stirred at room temperature for 1 hour. The mixture was evaporated to dryness to give 1-spiro[piperidine-4,4′-pyrrolo[2,1-c][1,4]benzoxazine]-1′-ylethanone hydrochloride (499 mg, 99%) which was used without further purification. ESI-MS m/z talc. 282.1, found 283.3 (M+1)+; Retention time: 0.86 minutes (3 min run).

Provenance & Evidence