Hydrochloric Acid → 1-isopropyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

To methyl 1-isopropyl-2-oxo-1,2-dihydropyridine-4-carboxylate (225 mg) was added NaOH (550 μL of 25% w/w, 4.3 mmol) and water (0.6 mL). The mixture was rapidly stirred and heated at 50° C. for 1 h. The mixture was cooled, acidified to pH 2 with 6N aq. HCl and the solids collected, rinsing with water and ACN (2×). The solid was dried in vacuo to give 1-isopropyl-2-oxo-pyridine-4-carboxylic acid as a white solid. ESI-MS m/z calc 181.2, found 182.3 (M−1)−. Retention time: 0.86 minutes (3 min run).

Provenance & Evidence